Unmet needs in CCA — 1 of 3

Diagnosis of CCA presents significant clinical challenges

CCA is usually asymptomatic in its early stages, often resulting in late diagnosis when patients are already at an advanced stage7,10


of iCCA cases are diagnosed because of an incidental finding, owing to non-specific symptoms7,11


of patients with eCCA present with painless jaundice; 10% present with acute cholangitis5,10

Lack of absolute diagnostic criteria and low specificity of diagnostic modalities make diagnosis of CCA difficult7,8,10

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What are the symptoms of advanced CCA?