Molecular profiling for early patient identification — 2 of 2

Testing for FGFR2 fusions or rearrangements can inform treatment decisions in CCA

The high frequency of actionable alterations in patients with CCA strongly supports the use of molecular testing in this population14

FGFR2 fusions have a wide range of fusion partners.14 Therefore, to identify patients with FGFR2 fusions, it is important to select an appropriate assay that:

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Can detect FGFR2 fusions (which are distinct from FGFR2 point mutations)14,21,22

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Can detect all FGFR2 fusions, including those with known or unknown fusion partners14,21,22

ESMO recommends parallel sequencing of several genes using focused NGS over single gene testing in patients with advanced disease.12